Curly tail: a 50-year history of the mouse spina bifida model

The Family History of Spina Bifida Cystica.

589 T HIS STUDY iS conceriled with the family history of 722 infants who were horn with spina bifida cystica (meningomyelocele, myelocele and meningocele) and who were referred to the Children’s Hospital, Sheffield, for surgical treatment. No cases were excluded from this investigation. None of the infants or children were referred for genetic advice hecautse of special problems, and if there w...

Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model.

Neural tube defects (NTDs), such as spina bifida, are common and severe birth defects in humans but the underlying causes are poorly understood. The pathogenesis and etiology of spina bifida in the curly tail mouse closely resemble defects in humans, providing a well-characterized model of NTDs. Grainyhead-like-3 (Grhl3), which encodes a transcription factor, was recently identified as a candid...

The Treatment of Spina Bifida

are glad to have a full and authoritative account of it provided by the originator. The work is enriched by the addition of Professor Humphry's drawings, and by a special account of the pathology of spina bifida from the pen of Professor Cleland. The author modestly refers to the report of the Clinical Society on his mode of treatment with some gratitude, and at the same time with a certain amo...

Spina Bifida (Myelomeningocele)

Spina bifida--a vanishing nightmare?

Detailed analysis is presented on the dramatic decline in spina bifida births and other congenital central nervous system defects in the past 12 years, in both Sheffield and the rest of Great Britain. In Sheffield, there was an average of 20 spina bifida births per year up to 1972, but since then there has been a progressive fall to only one in 1984. This decrease may be partly attributable to ...